منابع مشابه
Role of Cytokines in Pathophysiology of Asthma
The worldwide incidence, morbidity and mortality of asthma are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approximately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of a novel mediator known as ‘pleiotropic cyto...
متن کاملNeurovascular and neuroimmune aspects in the pathophysiology of rosacea.
Rosacea is a common skin disease with a high impact on quality of life. Characterized by erythema, edema, burning pain, immune infiltration, and facial skin fibrosis, rosacea has all the characteristics of neurogenic inflammation, a condition induced by sensory nerves via antidromically released neuromediators. To investigate the hypothesis of a central role of neural interactions in the pathop...
متن کاملPathophysiology of asthma.
1. Our understanding of asthma and its therapy has changed markedly over the last few years, particularly with the application of molecular and cell biology and the discovery of new and more specific pharmacological tools. 2. Many inflammatory cells participate in the inflammatory process in asthma and mediate a complex mixture of mediators. Cytokines are of particular importance as mediators o...
متن کاملThe pathophysiology of asthma.
Because postmortem studies of humans provide little information on the initial pathophysiologic events in asthma, animal models have been developed. Recently the Ascaris-allergic rhesus monkey has provided an opportunity to examine the onset of pathophysiologic changes following challenge and to correlate them with airway structure. These studies have suggested that the initial interaction betw...
متن کاملAsthma update: epidemiology and pathophysiology.
Introduction Asthma continues to be the leading serious chronic illness among children, responsible for 10 million lost school days each year and costing more than $12 billion per year. Asthma is not a series of episodic events over time, but a state of airway inflammation and hyperresponsiveness that has variable manifestations within a given patient and between individuals. In this first of t...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.663535